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A working model of the MecA-ClpCP system. In this highly dynamic system, the assembly and disassembly of the ClpCP protease are triggered by appearance and disappearance of MecA. A key to this system is that MecA itself is rapidly degraded by the ClpCP protease as soon as MecA accomplishes the task of ClpCP assembly. This dynamic system may ensure rapid response to changes in bacteria. The exact molar ratio between MecA and ClpC, although shown here as 1:1, remains to be determined.
