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. 2009 Sep 21;284(46):31587–31596. doi: 10.1074/jbc.M109.049577

FIGURE 10.

FIGURE 10.

Multiple sequence alignment of the C-terminal region of E. coli GadB (UniProt code DCEB_ECOLI) and 14 of its orthologues/paralogues. Background shading indicates residues under purifying selection in a Ka/Ks ratio analysis of coding sequences (the darker the shading the stronger the purifying selection, light gray corresponds to SELECTON score 5, dark gray corresponds to 6, and black corresponds to 7). A black square denotes the last residue (Pro452) of the folded core of GadB, after which the 14-residue-long C-terminal tail begins. The other sequences in the alignment are from: S. flexneri (DCEB_SHIFL), Shigella dysenteriae 1012 (B3WXK1_SHIDY), E. coli GadA (DCEA_ECOLI), Escherichia fergusonii (B7LRF1_ESCF3), Escherichia albertii TW07627 GadA (B1EHJ2_9ESCH), E. fergusonii GadA (B7LP95_ESCF3), Yersinia enterocolitica serotype O:8 (A1JR00_YERE8), Edwardsiella tarda (Q8GF15_EDWTA), Trichomonas vaginalis G3 (A2DC49_TRIVA), Brucella ceti str. Cudo (C0G9R8_9RHIZ), Akkermansia muciniphila (B2UN99_AKKM8), Bordetella avium (Q2KVV2_BORA1), Brucella suis (A9WY34_BRUSI), and Brucella ovis (A5VU56_BRUO2).