TABLE 2.
Expression of genes regulating hepatic lipid metabolism in mice fed the control, MCD, MCD + homocysteine, or homocysteine diets for 14 days
Relative expression, mean ± S.D. of n = 5–7, is shown.
| Control | MCD | MCD + homocysteine | Homocysteine | |
|---|---|---|---|---|
| HMG-CoAR | 1.06 ± 0.37 | 1.64 ± 0.48a | 1.04 ± 0.21b | 0.80 ± 0.25b |
| SREBP-2 | 1.15 ± 0.59 | 1.46 ± 0.54 | 0.94 ± 0.25b | 0.88 ± 0.33b |
| SR-B1 | 1.02 ± 0.20 | 1.50 ± 0.92 | 0.88 ± 0.28 | 1.16 ± 0.75 |
| SREBP-1c | 1.05 ± 0.40 | 1.11 ± 0.77 | 0.83 ± 0.38 | 1.30 ± 0.77 |
| LDL-R | 1.07 ± 0.43 | 1.59 ± 0.87 | 1.66 ± 0.54 | 1.00 ± 0.50 |
| SCD-1 | 1.06 ± 0.38 | 0.14 ± 0.07a | 0.37 ± 0.15a,b | 0.84 ± 0.11b |
a p < 0.05 versus Control.
b p < 0.05 versus MCD.