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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Bioorg Med Chem. 2009 Oct 12;17(23):8003–8011. doi: 10.1016/j.bmc.2009.10.011

Scheme 1a.

Scheme 1a

aReagents & conditions: a) 6-chloropurine, TMSOTf, ClCH2CH2Cl, rt to 80 °C; b) R2NH2, Et3N, EtOH, rt; c) 80% AcOH, 70 °C; d) TBSOTf, pyridine, 50 °C; e) NaOMe, MeOH