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. 2009 Oct 4;14(1):119–142. doi: 10.1007/s00792-009-0280-0

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© The Author(s) 2009

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Fig. 3 — Reconstructed CCM of S. solfataricus. Identified CCM reactions (enzyme abbreviations boxed) involved in the branched ED and the EMP pathway [reactions numbered, corresponding to Table 3)], the citric acid cycle including the glyoxylate shunt (dotted arrow) the reversed ribulose monophosphate pathway, C3/C4 conversions (dashed arrow) as well as glycogen and trehalose metabolism. Intermediates: DHAP dihydroxy acetonephosphate, Ery4P erythrose 4-phosphate, F6P fructose 6-phosphate, fructose 1,6P₂, fructose 1,6-bisphosphate, GAP glyceraldehyde 3-phosphate, G6P glucose 6-phosphate, KD(P)G 2-Keto-3-deoxy-6-(phospho)gluconate, KD(P)Gal 2-Keto-3-deoxy-6-(phospho)galactonate. Enzymes (including EC number): ACN aconitase (EC 4.2.1.3), CS citrate synthase (EC 2.3.3.1), ENO enolase (6; EC 4.2.1.11), FBPA fructose-1,6-bisphosphate aldolase (EC 4.1.2.13), FBPase fructose-1,6-bisphosphatase (EC 3.1.3.11), FumR fumarate hydratase (EC 4.2.1.2), GA glucan-1,4-α-glucosidase (EC 3.2.1.3), GAD gluconate dehydratase (2; EC 4.2.1.39), GADH glyceraldehyde dehydrogenase (4; EC 1.2.1.3), GAPDH glyceraldehyde-3-phosphate dehydrogenase (9; EC 1.2.1.12/13), GAPN non-phosphorylating GAP dehydrogenase (11; EC 1.2.1.9), GDH glucose dehydrogenase (1A; EC 1.1.47), GK glycerate kinase (5; EC 2.7.1-), GL gluconolactonase (1B; EC 3.1.17), GLGA glycogen synthase (EC 2.4.1.11), GLGP glycogen phosphorylase (EC 2.4.1.1), ICL isocitrate lyase (EC 4.1.3.1), IDH isocitrate dehydrogenase (EC 1.1.1.41), KD(P)GA KD(P)G aldolase (3; active on KDG as well as KDPG; EC 4.1.2.-), KDGK KDG kinase (8; EC 2.7.1.45), MAE malic enzyme (EC 1.1.1.38), MDH malate dehydrogenase (EC 1.1.1.37), MS malate synthase (EC 2.3.3.9), OOR α-oxoglutarate ferredoxin oxidoreductase (EC 1.2.7.3), PEPC PEP carboxylase (EC 4.1.1.31), PEPCK PEP carboxykinase (EC 4.1.1.32), PEPS phosphoenolpyruvate synthetase (13; EC 2.7.9.2), PGAM phosphoglycerate mutase (12; EC 5.4.2.1), PGI glucose-6-phosphate isomerase (EC 5.3.1.9), PGK phosphoglycerate kinase (10; EC 2.7.2.3), PGM phosphoglucomutase (EC 5.4.2.2), PHI/HPS 3-hexulose-6-phosphate isomerase/3-hexulose-6-phosphate synthase (EC 5.-.-.-/4.1.2.-), PK pyruvate kinase (7; EC 2.7.1.40), POR pyruvate synthase (EC 1.2.7.1), PRS ribose phosphate pyrophosphokinase (EC 2.7.6.1), PYC pyruvate carboxylase (EC 6.4.1.1), RBSK ribokinase (EC 2.7.1.15), RPI ribose-5-phosphate isomerase (EC 5.3.1.6), SDH succinate dehydrogenase (EC1.3.99.1), Succ-CoA Syn succinyl-cenzymA synthetase (EC 6.2.1.5), TIM triosephosphate isomerase (EC 5.3.1.1), TK transketolase (EC 2.2.1.1), TreT trehalose glycosyltransferring synthase (2.4.1.B2), TreY maltooligosyltrehalose synthase (EC 5.4.99.15), TreZ trehalose hydrolase (EC 3.2.1.141)