Table 1.
Estimated plasma pharmacokinetic parameters for total and extractable taxane and native PTX
| Drug injected | Half-live (h) | T max (h) | C max (µg/ml) | C last (µg/ml) | AUClast (h × µg/ml) | Vz (ml/kg) | Clearance (ml/h kg) | |
|---|---|---|---|---|---|---|---|---|
| PTX | ||||||||
| Total taxane | 59.9 | 0.166 | 60.5 | 0.036 | 146.3 | 23,167.8 | 267.7 | |
| Extractable taxane | 34.8 | 0.166 | 26.6 | 0.018 | 56.9 | 34,670.2 | 691.9 | |
| Native PTX | 31.6 | 0.166 | 11.6 | 0.0014 | 31.4 | 57,967.4 | 1,273.4 | |
| PGG–PTX | ||||||||
| Total taxane | 296.2 | 0.5 | 517.1 | 0.085 | 3,454.4 | 4,896.7 | 11.5 | |
| Extractable taxane | 253.1 | 0.166 | 31.9 | 0.065 | 279.4 | 48,204.1 | 132 | |
| Native PTX | 68.1 | 0.166 | 18.3 | 0.0197 | 125.7 | 30,805.9 | 313.4 | |
T max time after injection at which maximum concentration was detected; C max maximum concentration measured; C last concentration at last time point measured, 340 h; AUClast area under the concentration times time curve from 0 to 340 h; Vz estimated volume of distribution