TABLE 1. Odds Ratios and 95% Confidence Intervals for Adenocarcinoma of the Distal Stomach and Esophagus and Nitrate Concentrations in Nebraska Public Water Supplies (1965–1984)a.
Stomach Cancer | Esophagus Cancer | ||||||
---|---|---|---|---|---|---|---|
Controls | Cases | ORb | (95% CI) | Cases | ORc | (95% CI) | |
Nitrate in drinking water | |||||||
Years >10 mg/L nitrate-N | |||||||
0 | 218 | 54 | 1.0 | 57 | 1.0 | ||
1–8 | 55 | 12 | 1.0 | (0.5–2.0) | 12 | 0.8 | (0.4–1.8) |
9+ | 48 | 13 | 1.1 | (0.5–2.3) | 15 | 0.9 | (0.4–1.9) |
P for trend: | 0.672 | 0.384 | |||||
Average nitrate level 1965–1984 (mg/L nitrate-N) | |||||||
<2.45 | 80 | 17 | 1.0 | 17 | 1.0 | ||
2.45–<2.58 | 80 | 29 | 2.1 | (1.0–4.4) | 27 | 2.1 | (1.0–4.6) |
2.58–4.32 | 80 | 16 | 1.2 | (0.5-2.6) | 21 | 1.2 | (0.5–2.7) |
>4.32 | 81 | 17 | 1.2 | (0.5–2.7) | 19 | 1.2 | (0.6–2.7) |
P for trend | 0.946 | 0.519 |
Includes those with 70% or more of their person-years after 1964 with Nebraska public water supply nitrate estimates;
Odds ratios adjusted for year of birth, gender, education, smoking, alcohol;
Odds ratios adjusted for year of birth, gender, body mass index, smoking, alcohol.