TABLE 2. Odds Ratios and 95% Confidence Intervals for Adenocarcinoma of the Distal stomach and Esophagus and Nitrate and Nitrite from Dietary Sourcesa.
Distal Stomach Cancer | Esophagus Cancer | ||||||
---|---|---|---|---|---|---|---|
Controls | Cases | ORb | (95% CI) | Cases | ORc | (95% CI) | |
Diet nitrite and nitrate from animal sources (mg/day nitrate plus nitrite) | |||||||
<3.8 | 99 | 19 | 1.0 | 14 | 1.0 | ||
3.8–<5.7 | 99 | 31 | 1.6 | (0.8–3.2) | 17 | 0.7 | (0.3–1.6) |
5.7–<8.3 | 99 | 25 | 1.8 | (0.8–3.8) | 28 | 1.7 | (0.7–4.1) |
8.3+ | 100 | 29 | 1.6 | (0.7–3.7) | 39 | 2.2 | (0.9–5.7) |
P for trend | 0.352 | 0.015 | |||||
Diet nitrite from plant sources (mg/day nitrite) | |||||||
<0.36 | 94 | 23 | 1.0 | 23 | 1.0 | 1.0 | |
0.36–<0.52 | 102 | 22 | 1.1 | (0.4–2.7) | 28 | 1.1 | (0.5–2.3) |
0.52–<0.67 | 101 | 29 | 0.8 | (0.3–2.2) | 17 | 0.6 | (0.2–1.3) |
0.67+ | 100 | 30 | 1.1 | (0.3-3.4) | 30 | 1.0 | (0.4–2.4) |
P for trend | 0.275 | 0.438 | |||||
Diet nitrate from plant sources (mg/day nitrate-nitrogen) | |||||||
<16.9 | 99 | 24 | 1.0 | 29 | 1.0 | ||
16.9–<26.2 | 99 | 28 | 1.2 | (0.6–2.5) | 27 | 0.9 | (0.5–1.8) |
26.2–<38.8 | 99 | 26 | 1.4 | (0.7–2.9) | 18 | 0.6 | (0.3–1.3) |
>38.8 | 100 | 26 | 1.6 | (0.7–3.6) | 24 | 0.8 | (0.3–1.8) |
P for trend | 0.266 | 0.121 |
Excluded those with >20% unknown foods;
Odds ratios adjusted for year of birth, gender, education, smoking, alcohol, total calories, vitamin C, fiber, carbohydrate;
Odds ratios adjusted for year of birth, gender, body mass index, smoking, alcohol, total calories, vitamin A, folate, riboflavin, zinc, protein, carbohydrate.