Table 2.
28 genes downregulated by HIF-1alpha more than 2.0-fold in three pairwise comparisons
| UniGeneID | Gene name | Gene Symbol | Fold change(ratio ≥ 2) | ||
|---|---|---|---|---|---|
| Ad5-HIF-1alpha/Ad5 | Ad5-siHIF-1alpha/Ad5 | Hypoxia /normoxia |
|||
| Transport | |||||
| Hs.666728 | Na+/H+ exchanger domain containing 1 | NHEDC1 | -27.86 | 9.86 | -12.33 |
| Hs.666367 | potassium voltage-gated channel, Shal-related subfamily, member 3 | KCND3 | -16.00 | 6.13 | -11.82 |
| Hs.581021 | signal-regulatory protein alpha | SIRPa | -4.93 | 3.10 | -3.72 |
| Hs.504317 | solute carrier family 16, member 14 (monocarboxylic acid transporter 14) | SLC16A14 | -4.59 | 2.46 | -4.30 |
| Hs.118695 | potassium voltage-gated channel, subfamily G, member 1 | KCNG1 | -2.13 | 2.35 | -3.17 |
| Hs.158748 | solute carrier family 35, member F3 | SLC35F3 | -2.06 | 2.76 | -2.55 |
| Hs.443625 | collagen, type III, alpha 1 | COL3A1 | -2.29 | 2.16 | -3.78 |
| Transcription | |||||
| Hs.458406 | undifferentiated embryonic cell transcription factor 1 |
KCNG1 | -36.76 | 12.17 | -45.69 |
| Hs.511848 | zinc finger protein 569 | ZNF569 | -12.13 | 7.61 | -15.33 |
| Hs.412196 | intraflagellar transport 57 homolog | IFT57 | -8.58 | 4.38 | -7.36 |
| Hs.533977 | thioredoxin interacting protein | TXNIP | -5.28 | 3.10 | -5.01 |
| Hs.4779 | GATA zinc finger domain containing 2B | GATAD2B | -3.48 | 2.31 | -6.30 |
| Hs.9521 | zinc finger protein 92 | ZNF92 | -2.83 | 2.09 | -3.19 |
| Hs.490273 | cAMP responsive element binding protein3-like 2 |
CREB3L2 | -2.07 | 2.00 | -3.12 |
| Hs.524248 | zinc finger protein 362 | ZNF362 | -2.00 | 2.67 | -4.78 |
| Growth factors/cytokines | |||||
| Hs.485572 | suppressor of cytokine signaling 2 | SOCS2 | -6.06 | 3.06 | -7.12 |
| Hs.450230 | insulin-like growth factor binding protein 3 |
IGFBP3 | -4.02 | 2.17 | -5.73 |
| Hs.8867 | cysteine-rich, angiogenic inducer, 61 | CYR61 | -3.03 | 2.18 | -3.77 |
| Hs.289008 | nuclear undecaprenyl pyrophosphate- synthase 1 homolog |
NUS1 | -2.83 | 2.13 | -4.01 |
| Hs.699288 | neural precursor cell expressed, developmentally down-regulated 9 | NEDD9 | -2.64 | 2.26 | -2.57 |
| Protein amino acid phosphorylation | |||||
| Hs.370503 | FYN binding protein (FYB-120/130) | FYB | -6.06 | 3.97 | -4.71 |
| Hs.460355 | protein kinase C, beta 1 | PRKCB1 | -3.25 | 2.56 | -4.30 |
| Hs.390729 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 | ERBB4 | -2.46 | 2.11 | -3.89 |
| Hs.654491 | receptor tyrosine kinase-like orphan receptor 1 | ROR1 | -2.47 | 2.32 | -4.56 |
| Hs.653377 | insulin-like growth factor 1 receptor | IGF1R | -2.00 | 2.89 | -3.11 |
| Other down-regulated gene expression | |||||
| Hs.606356 | pleckstrin homology domain interacting protein | PHIP | -17.15 | 4.76 | -10.03 |
| Hs.567359 | X-ray repair complementing defective repair in Chinese hamster cells 4 | XRCC4 | -8.00 | 6.21 | -5.69 |
| Hs.502182 | brain-derived neurotrophic factor | BDNF | -2.30 | 2.14 | -2.18 |