Table 3.
ECHRS Atopy vs. controls | |||||||
---|---|---|---|---|---|---|---|
SNP | Gene | MAF | Chromosome | Position (build36) | Pooling | Replication | Combined |
rs11124858* | SGK493 | 0.367 | 2 | 42113828 | 0.0021 | 0.0318 | 0.0007† |
rs13409978* | SGK493 | 0.122 | 2 | 42119206 | 0.0007† | 0.0124 | 0.0001† |
rs4952590** | SGK493 | 0.141 | 2 | 42130425 | 0.0001† | 0.0008† | 1.9 × 10-6† |
rs1440095 | SGK493 | 0.379 | 2 | 42143170 | 0.0098 | 0.1078 | 0.0105 |
rs10934938 | COL29A1 | 0.23 | 3 | 131596325 | 0.1158 | 0.0291 | 0.0056 |
rs9402839* | MAP3K5 | 0.138 | 6 | 137036903 | 0.0355 | 0.0524 | 0.0099 |
rs9494554** | MAP3K5 | 0.095 | 6 | 137038675 | 0.0306 | 0.0035 | 0.0005† |
rs12483377* | COL18A1 | 0.108 | 21 | 45755537 | 0.0046 | 0.0607 | 0.0030 |
*SNPs found associated in the pooling-based GWA or their perfect tags (r2 = 0.8) used as substitutes in the genotyping design.
**SNPs that remained significant after a 5% FDR in the pooling-based GWA
†P-values that remain significant after Bonferroni correction (46 SNPs, p ≤ 0.001)