Table 2.
Association study of FTO rs9939609 variant with overweight and obesity
| Group | n | Genotype, n (%) | MAF, % | OR (95% CI) | P | HWE | ||
|---|---|---|---|---|---|---|---|---|
| TT | TA | AA | ||||||
| Normal weight | 607 | 242 (40) | 277 (46) | 88 (14) | 37 | 0.544 | ||
| Overweight | 454 | 169 (37) | 206 (45) | 79 (17) | 40 | 1.124 (0.942-1.341) | 0.194 | 0.242 |
| Obese | 54 | 16 (30) | 29 (54) | 9 (17) | 44 | 1.294 (0.870-1.927) | 0.203 | 0.588 |
Data are number of subjects in each group, at age 50 years, and number of subjects for each genotype (% in each group). Minor allele frequency (MAF) for each group is given in percentage. Odds ratio (OR) with a 95% confidence interval (CI) was calculated assuming an additive model. Association with overweight and obesity was determined comparing subjects with normal weight (BMI < 25 kg/m2 ) and overweight (BMI = 25 kg/m2 ) and subjects with normal weight (BMI < 25 kg/m2 ) and obesity (BMI ≥ 30 kg/m2 ), respectively. HWE indicate p-values for deviation from Hardy-Weinberg Equilibrium.