Table 1.
Association between HIF-1α and clinicopathological factors
| Factors | No. of patients | HIF-1α | ||
|---|---|---|---|---|
| Positive expression | χ2 | P | ||
| Age | ||||
| <60 | 24 | 15(62.5%) | 0.839 | 0.363 |
| ≥ 60 | 47 | 24(51.1%) | ||
| Sex | ||||
| Male | 43 | 24(55.8%) | 0.034 | 0.853 |
| Female | 28 | 15(53.6%) | ||
| Tumor size | ||||
| <5 cm | 31 | 17(54.8%) | 0.000 | 0.989 |
| ≥ 5 cm | 40 | 22(55%) | ||
| Differentiation grade |
||||
| Poor | 11 | 4(36.4%) | 2.233 | 0.327 |
| Moderate | 48 | 27(56.3%) | ||
| Well | 12 | 8(66.7%) | ||
| Invasion Depth | ||||
| T1 + T2 | 10 | 6(60%) | 0.121 | 0.728 |
| T3 + T4 | 61 | 33(54.1%) | ||
| Tumor stage | ||||
| I+II | 42 | 15(35.7%) | 15.336 | <0.001 |
| III+IV | 29 | 24(82.8%) | ||
| lymphnode matastasis, | ||||
| No | 44 | 17(38.6%) | 12.007 | <0.001 |
| Yes | 27 | 22(81.5%) | ||
| liver matastasis | ||||
| NO | 60 | 29(48.3%) | 6.806 | 0.009 |
| Yes | 11 | 10(90.1%) | ||