Skip to main content
. Author manuscript; available in PMC: 2009 Dec 23.
Published in final edited form as: J Immunol. 2009 Mar 15;182(6):3343–3347. doi: 10.4049/jimmunol.0713370

FIGURE 2.

FIGURE 2

Total phosphorylated tyrosine is significantly decreased in memory B cells of PTPN22 1858C/T subjects. Pan-tyrosine phosphorylation was assessed in B cells by intracellular flow cytometry. A, The percentage of unstimulated CD27+ (memory) and CD27- (naive) B cells with basal tyrosine phosphorylation is shown. B, B cells were activated for 2 min (2′) with anti-IgM/IgG. The log10-fold change in the mean fluorescence intensity of phosphorylation relative to the unstimulated control for CD27- naive and CD27+ memory B cells is shown. Black bars represent C/C samples (n = 6) and gray bars represent C/T samples (n = 6).