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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: J Biomed Mater Res A. 2010 Feb;92(2):667–682. doi: 10.1002/jbm.a.32368

Figure 4.

Figure 4

B-cell activation: Flow cytometric analysis of a highly Co reactive subject (SI>30) is shown to contain high B-cell (11% CD4+CD25+) activation and no increase in T-cell (3% CD19+CD69+) activation at 48 hours. Control activation for non-challenged T-cells and B-cells from this subject was below 3%. An increase in T-cell and B-cell activation is also demonstrated with Ni where a 8% and 12% increase in activation, respectively, is associated with a SI>90. Subject C: Group 1, 71 year old female with a history of dermal hypersensitivity to nickel and silver.