Table 2.
Results of metal reactivity (Metal reactive criteria: SI>2, p<0.05, t-test) and activation are shown for all study subjects where degree of metal reactivity is graded from low, medium and high by shading (see legend). “% Increase Activation” indicates the percent increase over untreated controls paired for each individual. Implanted TJA materials included cobalt-alloy (Co-alloy), titanium-alloy (Ti-alloy), Bone cement (PMMA) and ultrahigh molecular weight polyethylene (PE).
| Group | Subject | IMPLANT TYPE |
Sex | IN SITU months |
Age | Implant Material |
Dermal Allergy |
Cr Stim Index |
Cr T-cell Activation |
Cr B-cell Activation |
Co Stim Index |
Co T-cell Activation |
Co B-cell Activation |
Ni Stim Index |
Ni T-cell Activation |
Ni B-cell Activation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Group1 OA-Hist of Metal Sens |
1 | F | N/A | 43 | Jewelry |
**
|
*
|
*
|
87 |
45 |
57 |
8 |
9 |
3 |
||
| 2 | F | N/A | 71 | Silver |
4 |
*
|
2 |
33 |
*
|
7 |
93 |
5 |
9 |
|||
| 3 | F | N/A | 74 | Jewelry |
**
|
*
|
*
|
**
|
*
|
*
|
3 |
1 |
*
|
|||
| 4 | F | N/A | 46 | Jewelry |
**
|
*
|
*
|
**
|
*
|
*
|
9 |
*
|
*
|
|||
| 5 | F | N/A | 62 | Ni |
7 |
2 |
*
|
67 |
6 |
*
|
200 |
6 |
5 |
|||
| 6 | F | N/A | 55 | Ni - Jewerly |
**
|
*
|
*
|
**
|
*
|
*
|
27 |
5 |
1 |
|||
| 7 | F | N/A | 58 | ZippersJewelry |
**
|
*
|
*
|
**
|
*
|
*
|
6 |
6 |
*
|
|||
| 8 | F | N/A | 69 | Jewelry |
2 |
1 |
*
|
3 |
*
|
*
|
3 |
*
|
*
|
|||
| 9 | F | N/A | 66 | Ag and Au |
29 |
*
|
*
|
49 |
1 |
3 |
55 |
3 |
1 |
|||
| 10 | F | N/A | 74 | Ni |
**
|
*
|
*
|
**
|
*
|
*
|
3 |
*
|
*
|
|||
| 11 | M | N/A | 66 | Ni |
**
|
*
|
*
|
**
|
*
|
*
|
2 |
5 |
*
|
|||
| 12 | F | N/A | 54 | Ni | ** | * | * | ** | * | * | 2 | 3 | * | |||
|
| ||||||||||||||||
|
Group2a TJA-M-on-M |
13 | THA-MMSR | M | 83 | 47 | Co alloy, PMMA |
**
|
*
|
*
|
**
|
*
|
*
|
2 |
5 |
*
|
|
| 14 | THA-bilat MM | F | N/I | NA | Co alloy, PMMA | N/I |
**
|
*
|
*
|
**
|
*
|
*
|
**
|
*
|
*
|
|
| 15 | THA-MM | M | 10 | 67 | Co alloy, PMMA |
**
|
*
|
*
|
**
|
*
|
*
|
6 |
3 |
10 |
||
| 16 | THA-MMSR | M | * | 73 | Co alloy, PMMA | effusion problems |
**
|
*
|
*
|
35 |
17 |
5 |
**
|
*
|
*
|
|
| 17 | THA-MMSR | M | 34 | 58 | Co alloy, PMMA |
**
|
*
|
*
|
2 |
3 |
1 |
3 |
4 |
*
|
||
| 18 | THA-MMSR | M | 23 | 33 | Co alloy, PMMA | 2 | 1 | * | ** | * | * | 2 | 1 | 2 | ||
|
| ||||||||||||||||
|
Group2b TJA-Poly (pre-revision) |
19 | THA | F | 14 | 70 | N/I |
**
|
*
|
*
|
**
|
*
|
*
|
11 |
1 |
5 |
|
| 20 | TKA | F | 30 | 68 | UHMWPE, PMMA |
**
|
*
|
*
|
3 |
2 |
*
|
6 |
3 |
4 |
||
| 21 | THA | F | 17 | 58 | UHMWPE, PMMA | Jewelry |
**
|
*
|
*
|
**
|
*
|
*
|
**
|
*
|
*
|
|
| 22 | TKA | F | N/I | 50 | Co and Ti alloys, PE |
**
|
*
|
*
|
27 |
*
|
3 |
3 |
1 |
*
|
||
| 23 | TKA | F | N/I | 35 | Co and Ti alloys, PE |
**
|
*
|
*
|
2 |
*
|
2 |
3 |
*
|
*
|
||
| 24 | TKA | F | 7 | 64 | UHMWPE, PMMA |
3 |
3 |
16 |
**
|
*
|
*
|
7 |
3 |
10 |
||
| 25 | TKA | F | 10 | 77 | UHMWPE, PMMA |
2 |
1 |
*
|
**
|
*
|
*
|
12 |
3 |
*
|
||
| 26 | TKA | F | 18 | 53 | Co and Ti alloys, PE |
3 |
5 |
*
|
**
|
*
|
*
|
10 |
*
|
1 |
||
| 27 | TKA | F | 25 | 72 | N/I |
3 |
3 |
1 |
**
|
*
|
*
|
4 |
6 |
*
|
||
| 28 | TKA | F | 10 | 64 | Co and Ti alloys, PE |
**
|
*
|
*
|
**
|
*
|
*
|
**
|
*
|
*
|
||
| 29 | TKA | M | 9 | 66 | Co and Ti alloys, PE |
**
|
1 |
9 |
**
|
*
|
*
|
**
|
*
|
*
|
||
| 30 | TKA | M | 10 | 66 | Co and Ti aloys, PE |
**
|
*
|
*
|
**
|
*
|
*
|
2 |
*
|
20 |
||
| 31 | TKA | M | 52 | 55 | UHMWPE, PMMA |
**
|
1 |
|
**
|
*
|
*
|
**
|
2 |
|
||
| 32 | TKA | F | 12 | 49 | UHMWPE, PMMA |
**
|
*
|
*
|
29 |
*
|
2 |
**
|
*
|
*
|
||
| 33 | TKA | F | 18 | 40 | UHMWPE, PMMA | Jewelry |
**
|
*
|
*
|
**
|
*
|
*
|
3 |
2 |
*
|
|
| 34 | TKA | F | 60 | 50 | UHMWPE, PMMA | Ni +2 Patch Test |
4 |
1 |
1 |
**
|
*
|
*
|
6 |
2 |
1 |
|
| 35 | TKA | F | 19 | 60 | N/I | Jewelry, Glasses |
**
|
*
|
*
|
33 |
4 |
4 |
3 |
1 |
3 |
|
| 36 | TKA | F | 6 | 67 | UHMWPE, PMMA | Jewelry |
**
|
*
|
*
|
**
|
*
|
*
|
**
|
*
|
*
|
|
| 37 | TKA | F | 20 | 40 | UHMWPE, PMMA | Ni, Jewelry |
**
|
*
|
*
|
**
|
*
|
*
|
5 |
6 |
*
|
|
| 38 | TKA | F | N/I | N/I | N/I | N/I | 3 | * | * | ** | * | * | 5 | 1 | * | |
: SI > 8 = high reactivity
: 8> SI > 4 = moderate reactivity
: 4 > SI > 2 = mild reactivity
Surface Marker Activaiton = ≤ 1% increase in surface marker expresstion of actiavation over paired untreated controls
Proliferation = Stimulation Index (SI) < 2
NA=Not Applicable : none=No Information Available
MMSR=Metal on metal surface replacement, THA=total hip arthroplasty, TKA=total knee arthroplasty, Bilat-MM=Bilateral metal on metal total hip arthplast