Table 2. Results of haplotype analyses for SNPs in ZNF804A.
Associated haplotypes are shown in bold.
Block | HT | Freq. | fCases | fControls | Chi Sq | p | P |
---|---|---|---|---|---|---|---|
Block 1 | AC | 0.577 | 0.564 | 0.601 | 3.935 | 0.0473 | 0.558 |
GG | 0.288 | 0.302 | 0.263 | 5.531 | 0.0187 | 0.284 | |
GC | 0.135 | 0.134 | 0.137 | 0.062 | 0.8033 | 1 | |
Block 2 | CT | 0.557 | 0.567 | 0.541 | 1.956 | 0.1619 | 0.952 |
GC | 0.312 | 0.301 | 0.332 | 3.238 | 0.072 | 0.721 | |
CC | 0.13 | 0.132 | 0.127 | 0.171 | 0.6796 | 1 | |
Block 3 | TTAA | 0.304 | 0.322 | 0.272 | 8.626 | 0.0033 | 0.058 |
CTAA | 0.194 | 0.187 | 0.207 | 1.822 | 0.1771 | 0.964 | |
TTGC | 0.191 | 0.18 | 0.209 | 3.674 | 0.0553 | 0.611 | |
TGGC | 0.177 | 0.172 | 0.184 | 0.68 | 0.4094 | 1 | |
TTGA | 0.133 | 0.137 | 0.126 | 0.753 | 0.3856 | 1 | |
rs7597593 + Block 3 | TTTAA | 0.221 | 0.24 | 0.188 | 11.221 | 0.0008 | 0.017 |
CTTGC | 0.186 | 0.175 | 0.204 | 4.018 | 0.045 | 0.582 | |
CTGGC | 0.176 | 0.171 | 0.183 | 0.625 | 0.4293 | 1 | |
CCTAA | 0.12 | 0.112 | 0.134 | 3.23 | 0.0723 | 0.749 | |
TTTGA | 0.118 | 0.123 | 0.109 | 1.171 | 0.2792 | 0.998 | |
CTTAA | 0.082 | 0.082 | 0.081 | 0.016 | 0.8983 | 1 | |
TCTAA | 0.075 | 0.075 | 0.076 | 0.011 | 0.915 | 1 | |
CTTGA | 0.015 | 0.015 | 0.015 | 0.005 | 0.9419 | 1 | |
Block 4 | AG | 0.57 | 0.558 | 0.59 | 2.958 | 0.0855 | 0.789 |
GA | 0.315 | 0.327 | 0.295 | 3.329 | 0.0681 | 0.699 | |
GG | 0.115 | 0.115 | 0.115 | 0 | 0.9901 | 1 |
fCases/Controls: Frequency of indicated haplotype in cases and controls respectively; Chi-Sq: Chi-square test statistic; p and P: asymptotic and empirical permutation significance levels respectively. The unblocked, associated SNP rs7597593 was included in analysis with block 3 SNPs (including rs 1344706).