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. Author manuscript; available in PMC: 2010 Dec 29.
Published in final edited form as: Biochemistry. 2009 Dec 29;48(51):12305–12313. doi: 10.1021/bi901694s

Table 4.

Rate constants and deuterium kinetic isotope effects for reduction of PAO by para-substituted N,N'-dibenzyl-1,4-diaminobutanes.

pH 6.6 pH 8.6
Substituent kred (s−1) Dkred kred (s−1) Dkred
(CH3)2N 2.8 ± 0.3 1.4 ± 0.2 23.9 ± 0.6 1.7 ± 0.1
CH3O 1.19 ± 0.01 1.8 ± 0.1 4.1 ± 0.6 1.6 ± 0.2
CH3 0.66 ± 0.01 1.7 ± 0.1 1.84 ± 0.01 1.8 ± 0.1
H 0.21 ± 0.01 1.8 ± 0.1 0.42 ± 0.02 1.5 ± 0.1
Cl 0.48 ± 0.01 2.2 ± 0.1 0.80 ± 0.02 2.9 ± 0.1
Br 0.56 ± 0.02 1.7 ± 0.1 1.04 ± 0.06 1.5 ± 0.1
CF3 1.05 ± 0.02 1.8 ± 0.1 1.58 ± 0.06 1.3 ± 0.1