. Author manuscript; available in PMC: 2010 Dec 29.

Published in final edited form as: Biochemistry. 2009 Dec 29;48(51):12305–12313. doi: 10.1021/bi901694s

Table 6.

Correlation analyses of log k_cat/K_m and log k_cat with para-substituted N,N'-dibenzyl-1,4-diaminobutanes with hydrophobic, steric and electronic parameters at pH 8.6.

	k_cat/K_m		k_cat
Parameter	Coefficient	χ²	Coefficient	χ²
σ	0.63 ± 0.39	0.87	−0.61 ± 0.24	0.36
σ⁺	0.31 ± 0.23	1	−0.39 ± 0.13	0.28
σ⁻	0.76 ± 0.58	0.99	−0.49 ± 0.47	0.65
σ_I	2.00 ± 0.71	0.52	−0.32 ± 0.87	0.78
π	1.03 ± 0.27	0.35	−0.20 ± 0.40	0.76
V_W	0.06 ± 0.23	1.3	0.36 ± 0.08	0.17
E_S	−0.35 ± 0.18	0.71	−0.11 ± 0.16	0.35

V_W	n.d.		0.26 ± 0.08	0.072
σ⁺	n.d.		0.21 ± 0.09

V_W	0.23 ± 0.20	0.63	0.28 ± 0.06	0.060
σ	0.86 ± 0.41		−0.34 ± 0.13

π	1.06 ± 0.63	0.20	n.d.
σ_I	0.73 ± 0.29		n.d.

E_S	−0.13 ± 0.21	0.34	n.d.
σ_I	−0.22 ± 0.85		n.d.

π	−0.47 ± 0.54	0.28	n.d.
E_S	−0.30 ± 0.28		n.d.