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. 2010 Jan 15;6(1):e1000809. doi: 10.1371/journal.pgen.1000809

Figure 1. Loss of Spry1 rescues kidney development in Gdnf−/− or Ret−/− mice.

Figure 1

(A–E,H) excretory systems dissected from newborn mice of the indicated genotypes shown in whole mount. Note that the ureter in the Spry1−/− mutant is greatly expanded (black asterisk) and the kidneys are cystic (red asterisk). (F,G) H&E stained sections showing histology of cortex and nephrogenic zone in control (Spry1+/−) and Gdnf−/−;Spry1−/− kidneys, revealing a normal overall organization with well-differentiated glomeruli (*) (I,J) PAS-stained sections of wild-type and Ret−/−;Spry1−/− double mutant kidneys, showing normal overall organization with renal cortex, medulla, and outer nephrogenic zone. Abbreviations: Ad, adrenal gland; Bl, bladder; Co, cortex; Ki, kidney; Me, medulla, NZ, nephrogenic zone; Ur, ureter. Scale bars 1 mm in A-E and H, 100 µm in F,G,I,J.