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. 2010 Jan 15;6(1):e1000809. doi: 10.1371/journal.pgen.1000809

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Michos et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Kidneys of wild-type (A) and mutant genotypes (B–D), carrying Hoxb7/myrVenus, were excised at E12.5, cultured in vitro, and photographed at the indicated times. The Ret−/− Wolffian duct (B) failed to develop a ureter or kidney, while the Spry1−/− kidney (C) has multiple ureters (arrowheads), swollen UB tips and an enlarged common nephric duct (cnd). (D), in two examples of Gdnf−/−;Spry1−/− mutant kidneys, UB branching is retarded at E12.5, and subsequent branching in culture displays abnormal patterns (asterisks and arrowheads – see text) compared to wild-type.