Skip to main content
. 2010 Jan 15;6(1):e1000809. doi: 10.1371/journal.pgen.1000809

Figure 7. Fgf10 and Gdnf cooperate to support UB outgrowth and kidney development.

Figure 7

(A) Frequency of the failure of UB outgrowth at E11.5–12.5, and renal agenesis or hypoplasia at E17.5-P0. (B) Normal T-stage UB in an Fgf10+/− embryo at E11.5. (C–E) Three examples of UB formation or lack thereof in Fgf10+/−;Gdnf+/− E11.5 embryos. In (C), the UB is slightly retarded, in (D), the UB is severely delayed, and in (E) the UB is absent. (F–H), normal kidneys in wild-type and renal agenesis or hypoplasia in compound Fgf10/Gdnf mutants at P0. The wild-type in (F) has two normal kidneys, the double heterozygote in (G) has renal agenesis on one side and a hypoplastic kidney on the other, and the Fgf10−/−;Gdnf+/− example in (H) has bilateral agenesis. Ad, adrenal; Ki, kidney; Go, gonad. n = number of (potential) kidneys.