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. 2010 Jan 6;5(1):e8591. doi: 10.1371/journal.pone.0008591

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Coevolved (panel A, marked in red spheres) and non-coevolved (panel A, marked in blue sticks) active sites are projected onto the structure of a representative member (PDB code: 1EUQ) from Glutamyl-tRNA synthetase(GluRS)/Glutaminyl-tRNA synthetase (GlnRS) catalytic domain family (CDD code: CD00418). Here an edge connects two coevolved residues (red circles). Coevolved metal binding sites (panel B, marked in red spheres) are projected onto the 3D structure of a representative member (PDB code: 1LKO) from ferritin-like diiron-carboxylate protein domain family (CDD code: CD00657). Coevolved (panel C, marked in red spheres) and non-coevolved (panel C, marked in blue sticks) protein binding sites are projected onto the structure of a representative member (PDB code: 1JD1) from YjgF_YER057c_UK114_family (CDD code: CD00448). Protein structural and network representations were created using the PyMol [47] and Cytoscape [48] program.