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. 2010 Jan 6;5(1):e8591. doi: 10.1371/journal.pone.0008591

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Frequency of charge compensatory substitutions was calculated by counting the number of charge compensatory substitution quads (see Methods for details) for each pair of coevolved alignment columns. Frequency of charge compensatory substitutions (Y axis) is plotted against the spatial distances (X axis) between coevolved residue pairs.