Table 3. Functional coupling of coevolved sites.

FIS	Total coevolved pairs	% of coevolved site pairs
		Active site	Protein binding site	Ligand binding site	Metal binding site	Post-translational modification site	Miscellaneous site	Non Functional site
Active site	345	22.00	0.87	0.29	0.58	0.00	0.58	76.00
Protein binding site	285	1.05	21.40	1.05	0.00	0.00	0.35	76.14
Ligand binding site	189	0.53	1.59	8.47	0.53	0.00	0.00	88.89
Metal binding site	42	4.76	0.00	2.38	33.33	0.00	0.00	59.52
Post-translational modification site	3	0.00	0.00	0.00	0.00	0.00	0.00	100.00
Miscellaneous site	12	16.67	8.33	0.00	0.00	0.00	8.33	66.67