Table 4. Network properties of coevolved sites.

Sites	Average clustering coefficient	Mean shortest path	Average degree
All sites	0.49(±0.01)	2.74(±0.07)	3.31(±0.04)
All functional sites	0.19(±0.04)	1.41(±0.04)	1.55(±0.08)
Active sites	0.12(±0.05)	1.51(±0.06)	1.75(±0.17)
Ligand binding sites	0.05(±0.04)	1.32(±0.06)	1.29(±0.05)
Protein binding sites	0.18(±0.06)	1.39(±0.06)	1.44(±0.09)
Metal binding sites	0.32(±0.19)	1.41(±0.12)	2.00(±0.45)