Table 2.
Diet-dependent differentially expressed genes in islets
| Symbol per category | Description | Ratio (HF/CHF)a |
|---|---|---|
| Growth and development | ||
| Pax6 | Paired box gene 6 | 0.51 |
| Cdkn1b | Cyclin-dependent kinase inhibitor 1B | 0.40 |
| Pura | Purine rich element binding protein A | 0.37 |
| Dach1 | Dachshund 1 (Drosophila) | 0.35 |
| Metabolism | ||
| Gmds | GDP-mannose 4, 6-dehydratase | 5.02 |
| Ndufa1 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 | 4.80 |
| Sqle | Squalene epoxidase | 4.64 |
| Atp5b | ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit | 4.40 |
| Prps1 | Phosphoribosyl pyrophosphate synthetase 1 | 4.23 |
| Suclg1 | Succinate-CoA ligase, GDP-forming, alpha subunit | 4.14 |
| Pon3 | Paraoxonase 3 | 4.13 |
| Scd1 | Stearoyl-Coenzyme A desaturase 1 | 2.80 |
| Pfkfb2 | 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 0.41 |
| Cyp4a10 | Cytochrome P450, family 4, subfamily a, polypeptide 10 | 0.35 |
| Chkb | Choline kinase beta | 0.34 |
| Eno3 | Enolase 3, beta muscle | 0.34 |
| Mlxipl | MLX interacting protein-like | 0.29 |
| Gmds | GDP-mannose 4, 6-dehydratase | 0.20 |
| Protein processing and secretion | ||
| Rps27l | Ribosomal protein S27-like | 5.05 |
| Psmb7 | Proteasome (prosome, macropain) subunit, beta type 7 | 4.85 |
| Vamp8 | Vesicle-associated membrane protein 8 | 3.15 |
| Pcsk1 | Proprotein convertase subtilisin/kexin type 1 | 2.73 |
| Pcsk2 | Proprotein convertase subtilisin/kexin type 2 | 1.92 |
| Vti1b | Vesicle transport through interaction with t-SNAREs 1B homologue | 1.88 |
| Vamp5 | Vesicle-associated membrane protein 5 | 0.40 |
| Sec24a | SEC24 related gene family, member A (S. cerevisiae) | 0.38 |
| Signalling | ||
| Cck | Cholecystokinin | 9.25 |
| Rheb | RAS-homologue enriched in brain | 4.82 |
| Dusp6 | Dual specificity phosphatase 6 | 4.26 |
| Cacna1d | Calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.52 |
| Rps6kb2 | Ribosomal protein S6 kinase, polypeptide 2 | 0.40 |
| Nlgn1 | Neuroligin 1 | 0.34 |
| Vipr1 | Vasoactive intestinal peptide receptor 1 | 0.33 |
| P2ry6 | Pyrimidinergic receptor P2Y, G-protein coupled, 6 | 0.28 |
| Regulation of redox status | ||
| Txnip | Thioredoxin interacting protein | 4.14 |
| Prdx4 | Peroxiredoxin 4 | 3.10 |
| Prdx5 | Peroxiredoxin 4 | 2.74 |
| Cat | Catalase | 1.95 |
| Gpx1 | Glutathione peroxidase 1 | 2.26 |
| Other | ||
| Ctss | Cathepsin S | 12.98 |
| Cldn11 | Claudin 11 | 11.32 |
| Spp1 | Secreted phosphoprotein 1 | 4.55 |
| Alg5 | Asparagine-linked glycosylation 5 homolog | 4.54 |
| Tmem27 | Transmembrane protein 27 | 1.94 |
The top 44 differentially expressed genes (HF vs CHF) were categorised according to their known or putative biological function
aMean of five to six Affymetrix chips per condition; only genes with a significant fold-change were included (p ≤ 0.05)