TABLE 4.
RISK RECLASSIFICATION FOLLOWING INCORPORATION OF IFN-γ RESULTS. COMPARISON TO EXPANDED CLINICAL PREDICTION MODEL
| Model with Clinical Predictors Alone | Model with Clinical Predictors and Quantitative IFN-γ Results |
Percent Appropriately Reclassified | |||
|---|---|---|---|---|---|
| ≤5% risk | 5–20% risk | >20% risk | Total No. | ||
| In 65 patients who developed culture-positive disease | |||||
| ≤5% risk | 7 | 9 | 0 | 16 | 56 |
| 5–20% risk | 3 | 6 | 7 | 16 | 25 |
| >20% risk | 1 | 0 | 32 | 33 | −3 |
| Total No. | 11 | 15 | 39 | 65 | |
| In 595 patients who ruled out for active tuberculosis | |||||
| ≤5% risk | 334 | 121 | 0 | 455 | −27 |
| 5–20% risk | 20 | 34 | 14 | 68 | 9 |
| >20% risk | 9 | 18 | 45 | 72 | 38 |
| Total No. |
363 |
173 |
59 |
595 |
|
Net reclassification improvement = 3.7% (P = 0.31). Reclassification among patients who developed culture-positive disease = 18.5% (P < 0.01); reclassification among patients who ruled out for active tuberculosis = −14.8% (P = 1).