Figure 1.

Prognosis in AML strongly correlates with cytogenetic findings.¹⁸,¹⁹,²⁰,²¹ Favorable prognosis is associated with t(15;17), t(8;21), or inv(16) whether alone or in combination with other chromosomal abnormalities, with the possible exception of inv(16) or t(8;21) with complex karyotype. An intermediate prognosis is associated with normal karyotype or select abnormalities: +6, +8, −7q, −9q, −12p, +21, +22, −Y. Adverse outcome is associated with abnormal 3q, 11q, 17p, 20q, 21q, or with −5, −5q, −7, −7q, −9q, t(6;9), t(9;22), or with complex karyotype. Abnormalities of the MLL gene on 11q23 impart a dismal prognosis.^22,23 In children, poor survival is associated with monosomies or complex karyotype.⁵ (Adapted from Grimwade¹⁸ with permission).