Table 1.

2008 World Health Organization Classification of Acute Myeloid Leukemia and Related Tumors

AML with recurrent genetic abnormalities

AML with t(8;21)(q22;q22) RUNX1-RUNX1T1 (CBFA-ETO)

AML with inv(16)(p13q22) or t(16;16)(p13;q22) CBFB-MYH11

APL with t(15;17)(q22;q11–12) PML-RARA

AML with t(9;11)(p22;q23) MLLT3-MLL and other balanced translocations of 11q23 (MLL)

AML with t(6;9)(p23;q34) DEK-NUP214

AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) RPN1-EVI1

AML (megakaryoblastic) with t(1;22)(p13;q13) RBM15-MKL1

AML with mutated NPM1*

AML with mutated CEBPA*

Acute myeloid leukemia with myelodysplasia-related changes

Therapy-related myeloid neoplasms

AML, not otherwise specified

AML with minimal differentiation

AML without maturation

AML with maturation

Acute myelomonocytic leukemia

Acute monoblastic/monocytic leukemia

Acute erythroid leukemias

Acute megakaryoblastic leukemia

Acute basophilic leukemia

Acute panmyelosis with myelofibrosis

Myeloid sarcoma

Myeloid proliferations related to Down syndrome (+21)

Transient abnormal myelopoiesis

Myeloid leukemia associated with Down syndrome

Blastic plasmacytoid dendritic cell neoplasms

Adapted from Swerdlow et al.1

^*Provisional categories.