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. Author manuscript; available in PMC: 2009 Dec 24.
Published in final edited form as: Arch Gen Psychiatry. 2009 Sep;66(9):938–946. doi: 10.1001/archgenpsychiatry.2009.115

Figure 3.

Figure 3

The CA1 subfield is a site of dysfunction selectively associated with clinical features. A, Cerebral blood volume (CBV) measured in the CA1 subfield, but not the orbitofrontal cortex (OFC) or dorsolateral prefrontal cortex (DLPFC), was significantly elevated at baseline, comparing the prodromal subjects who clinically progressed to psychosis with those who did not. B, Individual CBV maps of the hippocampal formation are shown for a healthy control, a prodromal subject, and a patient with schizophrenia. The CBV maps are color coded such that warmer colors reflect higher CBV values. Higher CBV was observed in the CA1 subfield of the prodromal subject, and higher CBV was observed in the CA1 and subiculum in the patient with schizophrenia. C, CA1 CBV, but not OFC or DLPFC CBV correlated with positive symptoms, in particular, delusional severity. PANSS indicates Positive and Negative Symptom Scale.