Table 2.
Cerebral Blood Volumes by Subregion
| Mean (SD) |
|||
|---|---|---|---|
| Subregion | Control | Ultra–High-Risk | Schizophrenia |
| Anterior hippocampus | |||
| Entorhinal cortex | 1.56 (0.84) | 1.41 (0.92) | 1.29 (1.03) |
| Subiculum | 1.76 (0.88) | 1.60 (0.98) | 2.50 (1.38)a |
| CA1 subfield | 1.26 (0.47) | 1.48 (0.49) | 1.99 (0.82)b |
| CA3 subfield | 1.86 (1.18) | 1.69 (0.82) | 1.93 (1.48) |
| Dentate gyrus | 1.51 (1.02) | 0.78 (0.88) | 1.47 (1.00) |
| Posterior hippocampus | 1.98 (0.52) | 2.08 (0.51) | 1.88 (1.10) |
| Prefrontal cortex | |||
| Gyrus rectus | 2.13 (0.96) | 2.08 (0.60) | 1.92 (0.96) |
| Medial orbitofrontal cortex | 1.36 (1.06) | 2.03 (0.84) | 2.51 (1.00)b |
| Dorsolateral prefrontal cortex | 2.35 (0.56) | 2.09 (0.60) | 1.79 (0.84)c |
| Ventral striatum | |||
| Caudate | 1.78 (0.43) | 1.70 (0.63) | 2.05 (1.16) |
| Nucleus accumbens | 1.88 (0.52) | 2.16 (0.71) | 2.04 (1.16) |
| Putamen | 2.32 (0.52) | 1.98 (0.64) | 2.07 (0.84) |
| Amygdala | |||
| Dorsal nucleus | 1.30 (1.02) | 1.41 (1.61) | 1.22 (1.59) |
| Basolateral nucleus | 1.04 (1.03) | 1.49 (0.55) | 1.50 (1.03) |
P < .10 for controls vs patients with schizophrenia by analysis of variance.
P < .01 for controls vs patients with schizophrenia by analysis of variance.
P < .05 for controls vs patients with schizophrenia by analysis of variance.