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. Author manuscript; available in PMC: 2010 Dec 10.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7512–7527. doi: 10.1021/jm900016t

Scheme 5.

Scheme 5

Synthesis of compounds 57–60a

a Reagents and reaction conditions: (a) ethyl pyruvate, CH3COONa, EtOH, open vessel, 100 °C, 250 W, Pmax, 5 min, 90%; (b) PPA, 110 °C, 30 min, 60%; (c) 3 N NaOH, closed vessel, 110 °C, 150 W, 1 min, 95%; (d) SOCl2, absolute MeOH, 65 °C, 2 h, Ar stream, 96%.