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. Author manuscript; available in PMC: 2010 Dec 10.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7512–7527. doi: 10.1021/jm900016t

Scheme 3.

Scheme 3

Synthesis of Compounds 27 and 30a

a Reagents and reaction conditions: (a) NaH, bis(3,4,5-trimethoxyphenyl)disulfide, anhydrous DMF, closed vessel, 110 °C, 150 W, Pmax = 250 PSI, PowerMAX, 2 min; (b) (27) TMSDM, CH2Cl2/MeOH, 25 °C, 30 min, 79%; (c) (30) SOCl2, absolute EtOH, 65 °C, 2 h, Ar stream, 70%.