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. Author manuscript; available in PMC: 2010 Dec 10.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7512–7527. doi: 10.1021/jm900016t

Table 4.

Inhibition of Growth of HEK, M14 and U937 Cells by Compounds 24, 2729, 36, 39, and 41a

IC50 ± SD (nM)
compd HEKb M14c U937d
24 220±3 194±3 100±3
27 189±5 155±9 177±10
28 131±3 78±3 191±7
29 160±5 120±10 159±10
36 128±7 111±6 122±6
39 140±1 100±5 155±10
41 181±3 137±5 189±5
a

Growth inhibition of the indicated cell lines (MTT method); incubation time was 48 h.

b

HEK, human embryonic kidney 293 cells;

c

M14, human melanoma cells;

d

U937, human leukemic monocyte lymphoma cells.