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. 2009 Dec 11;6:37. doi: 10.1186/1742-2094-6-37

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Copyright ©2009 Miljković et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MP treatment ameliorates EAE in DA rats and decreases infiltration of cells into the CNS. DA rats were immunized with SCH-CFA. Commencing on the day when first neurological signs appeared (designated as day 1), DA rats were injected daily for 3 days with methylprednisolone (MP, 50 mg/kg body weight) or with phosphate-buffered saline (PBS). The rats were checked daily for clinical signs of EAE. For the determination of the clinical course of EAE, 19 animals per group (out of four independent experiments) were used. (A). Three hours after the last injection of MP some animals were sacrificed, and cells infiltrating spinal cord, splenocytes, peripheral blood cells, and draining lymph node cells were isolated and counted (B). *p < 0.05 represents statistically significant difference between MP and PBS group.