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. 2009 Dec 14;5:72. doi: 10.1186/1744-8069-5-72

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Copyright ©2009 Machelska et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Swim stress and POMC-MIDGE-NLS effects on inflammatory pain. Paw pressure thresholds (PPT) were measured at 4 days after induction of inflammation (white bars), then control MIDGE-NLS (50 μg; gray bars) or POMC-MIDGE-NLS (50 μg; black bars) were injected into inflamed paws and PPT were re-evaluated 24 h later (baseline, BL). Next, rats were exposed to cold water swim stress and PPT were re-examined 1 min and 5 min later. *p < 0.05, compared with the BL of control MIDGE-NLS; ⁺p < 0.05, compared with respective BL (two-way repeated measures ANOVA and Bonferroni t-test); ^#p < 0.001, compared with respective PPT of inflamed paws before vector injections (depicting the development of inflammatory hyperalgesia) (paired t-test).