Table 4.
Comparison of HLA haplotypes and genotypes in HIV-1 positive and population control groups
| Haplotype/Genotype | No. of HIV-1 Positive N (%) |
No. of Population Control N (%) |
P value | Corrected P value | Odds ratios | 95%CI |
|---|---|---|---|---|---|---|
| 2-locus Haplotype | ||||||
| A*11 B*46▲ | 50 (9.1) | 143 (5.8) | 0.005 | 0.012 | 1.630 | 1.15-2.32 |
| A*24 B*54▲ | 26 (4.7) | 57 (2.3) | 0.003 | 0.012 | 2.110 | 1.28-3.46 |
| A*01 B*37▲ | 16 (2.9) | 34 (1.4) | 0.017 | 0.017 | 2.160 | 1.13-4.07 |
| A*11 B*1502G▲ | 30 (5.5) | 220 (8.9) | 0.011 | 0.012 | 0.590 | 0.39-0.89 |
| 3-locus Haplotype | ||||||
| A*11 B*46 DRB1*09▲ | 35 (6.4) | 92 (3.7) | 0.007 | 0.032 | 1.760 | 1.16-2.68 |
| A*02 B*46 DRB1*08▲ | 30 (5.5) | 82 (3.3) | 0.022 | 0.038 | 1.690 | 1.07-2.64 |
| A*11 B*4001G DRB1*15▲ | 21 (3.8) | 29 (1.2) | <0.0001 | 0.0007 | 3.350 | 1.83-6.13 |
| A*02 B*4001G DRB1*04▲ | 11 (2.0) | 17 (0.7) | 0.008 | 0.032 | 2.960 | 1.29-6.70 |
| A*11 B*46 DRB1*08▲ | 11 (2.0) | 9 (0.4) | <0.0001 | 0.0007 | 5.600 | 2.15-14.74 |
| A*02 B*4001G DRB1*12▲ | 9 (1.6) | 16 (0.6) | 0.039 | 0.039 | 2.560 | 1.04-6.17 |
| A*11 B*1502G DRB1*12▲ | 7 (1.3) | 126 (5.1) | 0.0001 | 0.0007 | 0.240 | 0.10-0.54 |
| A*33 B*58 DRB1*13▲ | 9 (1.6) | 86 (3.5) | 0.036 | 0.039 | 0.460 | 0.22-0.96 |
| Homozygosity | ||||||
| A-A | 120 (21.9) | 590 (23.8) | 0.96 | 0.96 | 1.00 | 0.73-1.35 |
| B-B | 43 (7.8) | 198 (8.0) | 0.23 | 0.35 | 0.89 | 0.73-1.08 |
| DRB1-DRB1 | 61 (11.1) | 265 (10.7) | 0.23 | 0.35 | 1.13 | 0.93-1.36 |
| Serological group | ||||||
| Bw4-Bw4 | 61 (11.1) | 276 (11.1) | 0.35 | 0.96 | 0.89 | 0.71-1.12 |
| Bw6-Bw6 | 226 (41.2) | 1091 (44.1) | 0.96 | 0.96 | 0.98 | 0.68-1.40 |
| Bw4-Bw6 | 262 (47.7) | 1108 (44.8) | 0.84 | 0.96 | 1.04 | 0.77-1.41 |
"N" indicates the number of people with a given haplotype/genotype. The percentage is indicated in parentheses; P value with Yates' correction; CI, confidence interval.
▲: indicates P value and corrected P value (adjusted with False discovery rate for multiple testing) <0.05 of comparative distribution of haplotypes and genotypes in the HIV-1 positive and population control group.