Table 2.

Correlations of HIF-1α mRNA and protein with clinicopathological characters

	HIF-1α mRNA			HIF-1α protein
	low	high	P	low	high	P
Patients	68	42		71	39
Age(years)
≤52	28	26	0.049	32	22	0.320
>52	40	16		39	17
Sex
Male	57	38	0.40	57	38	0.017
Female	11	4		14	1
Hepatitis history
Yes	61	39	0.739	62	38	0.094
No	7	3		9	1
Preoperative AFP(ng/ml)
≤20	29	16	0.693	33	12	0.156
>20	39	26		38	27
Liver cirrhosis
Yes	59	34	0.428	56	37	0.029
No	9	8		15	2
ALT(U/L)
≤40	36	22	1.000	38	20	0.844
>40	32	20		33	19
Γ-GT(U/L)
≤54	30	14	0.318	31	13	0.316
>54	38	28		40	26
Tumor size (cm)
≤5	35	21	1.000	33	23	0.236
>5	33	21		38	16
Tumor encapsulation
Yes	31	18	0.845	32	17	1.000
No	37	24		39	22
Tumor number
Single	53	32	0.820	56	29	0.638
Multiple	15	10		15	10
Vascular invasion
Yes	26	25	0.033	27	24	0.027
No	42	17		44	15
BCLC stage
A	30	10	0.041	31	9	0.039
B + C	38	32		40	30
Tumor differentiation
I+II	40	18	0.119	36	22	0.690
III+IV	28	24		35	17
Prophylactic treatment
Yes	33	22	0.845	31	24	0.110
No	35	20		39	16

Detailed legends: Fisher's exact tests were used for all the analysis of correlations.