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Direct topical treatment with LXA4 down-regulates expression of key regulators of inflammatory angiogenesis. After suture injury corneas were treated with either saline alone or LXA4 (100 ng, t.i.d.) for 48 hours. mRNA expression was quantified for HO-1, VEGF-A, FLT4, and both LXA4 receptors (ALX-1, ALX-2) using a real-time PCR system. Relative expression was compared with a mouse positive mRNA control (n = 4, *P < 0.05).
