Figure 1.

Tgfbr2^dermalKO mice showed Cre-mediated recombination and loss of TGF-β responsiveness in the dermis. Histology of back skin from control and Tgfbr2^dermalKO mice was determined by H&E staining (A and B). β-galactosidase activity, associated with DNA recombination, was localized in back skin of control and Tgfbr2^dermalKO mice (C and D). Immunolocalization for phosphorylated-Smad2, indicating downstream TGF-β signaling, had differential expression in dermal fibroblasts of control and Tgfbr2^dermalKO mice (E and F). Scale bars: 20 μm (A–F); 10 μm (dashed area magnified in inset).