Table 2.
Protection of Δpm4 Cured Mice against Challenge with Wild-Type Parasites of P. berghei and P. yoelii
| Mouse strain | Infected with/cured from | Challenged with | Time of challenge (days)* | Challenge dose (no. of parasites)† | No. protected/no. challenged |
|---|---|---|---|---|---|
| BALB/c | Δpm4cl6 | P. berghei | 60 | 107 | 30/30‡ |
| BALB/c | Δpm4cl6 | P. berghei | 120 | 107 | 30/30‡ |
| BALB/c | Δpm4cl6 | P. berghei | 180 | 107 | 20/20 |
| BALB/c | Δpm4cl6 | P. berghei | 270 | 107 | 9/9 |
| BALB/c | Δpm4cl6 | P. berghei | 360 | 107 | 7/7 |
| C57BL/6 | Δpm4cl6 | P. berghei | 120 | 107 | 10/10‡ |
| NIH Swiss | 688cl3 | P. berghei | 44/60 | 106 | 6/6 |
| BALB/c | Δpm4cl6 | P. yoelii (17X) | 120 | 107 | 5/10 |
| BALB/c | Δpm4cl6 | P. yoelii (17X) | 120 | 106 | 10/10 |
| BALB/c | Δpm4cl6 | P. yoelii (17X) | 120 | 105 | 10/10‡ |
| BALB/c | Δpm4cl6 | P. yoelii (17X) | 120 | 104 | 10/10‡ |
| NIH Swiss | 688cl3 | P. yoelii (17X) | 44 | 106 | 5/5 |
*
Number of days after recovery from infection with Δpm4cl6 or 688cl3.
†
Mice were challenged by i.v. injection of infected erythrocytes.
‡
Three months after the initial challenge, 10 mice were rechallenged with 107 parasites and all mice remained protected.