Table 3.
Correlation between Methylation of Eight Genes and Progression of ATLL
|
SHP1 |
p16 |
DAPK |
hMLH1 |
MGMT |
p73 |
p15 |
HCAD |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M | U | M | U | M | U | M | U | M | U | M | U | M | U | M | U | |
| Normal PBMC | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 3 | 13 | 6 | 10 |
| HTLV-I carrier | 3 | 7 | 0 | 10 | 2 | 8 | 1 | 9 | 2 | 8 | 3 | 7 | 2 | 8 | 3 | 7 |
| P value | 0.046 | − | 0.138 | 0.385 | 0.138 | 0.046 | 1.000 | 1.000 | ||||||||
| Normal PBMC | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 3 | 13 | 6 | 10 |
| Smoldering type | 3 | 12 | 2 | 13 | 7 | 8 | 0 | 15 | 1 | 14 | 1 | 14 | 4 | 11 | 15 | 0 |
| P value | 0.101 | 0.226 | 0.002 | − | 0.484 | 0.484 | 0.685 | 0.000 | ||||||||
| Normal PBMC | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 3 | 13 | 6 | 10 |
| Chronic type | 3 | 2 | 0 | 5 | 3 | 2 | 0 | 5 | 2 | 3 | 1 | 4 | 2 | 3 | 5 | 0 |
| P value | 0.006 | − | 0.006 | − | 0.048 | 0.238 | 0.553 | 0.035 | ||||||||
| Normal PBMC | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 3 | 13 | 6 | 10 |
| Acute type | 12 | 3 | 0 | 17 | 8 | 7 | 3 | 12 | 0 | 15 | 0 | 15 | 3 | 12 | 13 | 2 |
| P value | 0.000 | − | 0.001 | 0.101 | − | − | 1.000 | 0.009 | ||||||||
| Normal PBMC | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 0 | 16 | 3 | 13 | 6 | 10 |
| Lymphoma type | 18 | 2 | 8 | 12 | 16 | 4 | 1 | 19 | 9 | 11 | 3 | 17 | 4 | 16 | 18 | 2 |
| P value | 0.001 | 0.005 | 0.000 | 1.000 | 0.002 | 0.557 | 0.675 | 0.045 | ||||||||
| HTLV-I carrier | 3 | 7 | 0 | 10 | 2 | 8 | 1 | 9 | 2 | 8 | 3 | 7 | 2 | 8 | 3 | 7 |
| Smoldering type | 3 | 12 | 2 | 13 | 7 | 8 | 0 | 15 | 1 | 14 | 1 | 14 | 4 | 11 | 15 | 0 |
| P value | 0.653 | 0.350 | 0.176 | 0.400 | 0.346 | 0.267 | 0.545 | 0.000 | ||||||||
| HTLV-I carrier | 3 | 7 | 0 | 10 | 2 | 8 | 1 | 9 | 2 | 8 | 3 | 7 | 2 | 8 | 3 | 7 |
| chronic type | 3 | 2 | 0 | 5 | 3 | 2 | 0 | 5 | 2 | 3 | 1 | 4 | 2 | 3 | 5 | 0 |
| P value | 0.287 | − | 0.167 | 0.667 | 0.407 | 0.593 | 0.407 | 0.019 | ||||||||
| HTLV-I carrier | 3 | 7 | 0 | 10 | 2 | 8 | 1 | 9 | 2 | 8 | 3 | 7 | 2 | 8 | 3 | 7 |
| Acute type | 12 | 3 | 0 | 15 | 8 | 7 | 3 | 12 | 0 | 15 | 0 | 15 | 3 | 12 | 13 | 2 |
| P value | 0.018 | − | 0.105 | 0.468 | 0.150 | 0.052 | 0.687 | 0.007 | ||||||||
| HTLV-I carrier | 3 | 7 | 0 | 10 | 2 | 8 | 1 | 9 | 2 | 8 | 3 | 7 | 2 | 8 | 3 | 7 |
| Lymphoma type | 18 | 2 | 8 | 12 | 16 | 4 | 1 | 19 | 9 | 11 | 3 | 17 | 4 | 16 | 18 | 2 |
| P value | 0.002 | 0.022 | 0.003 | 0.563 | 0.175 | 0.306 | 0.694 | 0.002 | ||||||||
| Smoldering type | 3 | 12 | 2 | 13 | 7 | 8 | 0 | 15 | 1 | 14 | 1 | 14 | 4 | 11 | 15 | 0 |
| Chronic type | 3 | 2 | 3 | 2 | 3 | 2 | 0 | 5 | 2 | 3 | 1 | 4 | 2 | 3 | 5 | 0 |
| P value | 0.131 | 0.553 | 0.500 | − | 0.140 | 0.447 | 0.483 | − | ||||||||
| Smoldering type | 3 | 12 | 2 | 13 | 7 | 8 | 0 | 15 | 1 | 14 | 1 | 14 | 4 | 11 | 15 | 0 |
| Acute type | 12 | 3 | 0 | 15 | 8 | 7 | 3 | 12 | 0 | 15 | 0 | 15 | 3 | 12 | 13 | 2 |
| P value | 0.003 | 0.241 | 0.500 | 0.112 | 0.500 | 1.000 | 0.500 | 0.241 | ||||||||
| Smoldering type | 3 | 12 | 2 | 13 | 7 | 8 | 0 | 15 | 1 | 14 | 1 | 14 | 4 | 11 | 15 | 0 |
| Lymphoma type | 18 | 2 | 8 | 12 | 16 | 4 | 1 | 19 | 9 | 11 | 3 | 17 | 4 | 16 | 18 | 2 |
| P value | 0.000 | 0.087 | 0.045 | 0.571 | 0.015 | 0.619 | 0.473 | 0.319 | ||||||||
| Chronic type | 3 | 2 | 0 | 5 | 3 | 2 | 0 | 5 | 2 | 3 | 1 | 4 | 2 | 3 | 5 | 0 |
| Acute type | 12 | 3 | 0 | 15 | 8 | 7 | 3 | 12 | 0 | 15 | 0 | 15 | 3 | 12 | 13 | 2 |
| P value | 0.366 | − | 0.604 | 0.399 | 0.053 | 0.250 | 0.366 | 0.553 | ||||||||
| Chronic type | 3 | 2 | 0 | 5 | 3 | 2 | 0 | 5 | 2 | 3 | 1 | 4 | 2 | 3 | 5 | 0 |
| Lymphoma type | 18 | 2 | 8 | 12 | 16 | 4 | 1 | 19 | 9 | 11 | 3 | 17 | 4 | 16 | 18 | 2 |
| P value | 0.166 | 0.116 | 0.343 | 0.800 | 0.622 | 0.617 | 0.343 | 0.633 | ||||||||
| Acute type | 12 | 3 | 0 | 15 | 8 | 7 | 3 | 12 | 0 | 15 | 0 | 15 | 3 | 12 | 13 | 2 |
| Lymphoma type | 18 | 2 | 8 | 12 | 16 | 4 | 1 | 19 | 9 | 11 | 3 | 17 | 4 | 16 | 18 | 2 |
| P value | 0.360 | 0.005 | 0.095 | 0.200 | 0.002 | 0.174 | 0.668 | 0.581 | ||||||||
Bold numbers indicate significant differences of methylation frequency (P < 0.05).