Table 5.

Simultaneous Methylation of Two Genes during Crisis or Progression of ATLL

	p16		DAPK		hMLH1		MGMT		p73		p15		HCAD
	M	U	M	U	M	U	M	U	M	U	M	U	M	U
SHP1
M	8	28	24	12	3	33	9	27	5	31	10	26	31	5
U	2	40	12	30	2	40	5	37	5	37	7	35	27	15
P value	0.038		0.001		0.657		0.152		1.000		0.279		0.038
p16
M			7	3	1	9	3	7	2	8	2	8	10	0
U			29	39	4	64	11	57	8	60	15	53	48	20
P value			0.173		0.506		0.373		0.608		1.000		0.057
DAPK
M					2	34	11	25	6	30	10	26	34	2
U					3	39	3	39	4	38	7	35	24	18
P value					1.000		0.009		0.500		0.279		0.000
hMLH1
M							0	5	1	4	1	4	5	0
U							14	59	9	64	16	57	53	20
P value							90.579		0.506		1.000		0.320
MGMT
M									4	10	4	10	10	4
U									6	58	13	51	48	16
P value									0.073		0.491		0.746
p73
M											3	7	7	3
U											14	54	51	17
P value											0.682		0.711
p15
M													15	2
U													43	18
P value													0.211

Fisher's exact test.

Bold numbers indicate significant differences of methylation frequency (P < 0.05).