TABLE 1.

Frequency of induced diabetes in LEW0.1WR1 rats

Treatment type	Group	Poly I:C	Virus	n	n (%) diabetic
Culture medium alone	1	No	None	16	0 (0)
Single viral inoculations*	2	No	KRV alone	8	3 (38)
	3	No	RCMV alone†‡	38	14 (37)
	4	No	Coxsackie B4 alone§	18	0 (0)
	5	No	Vaccinia alone‖	14	1 (7)
	6	No	H-1 alone	20	0 (0)
	7	Yes	None	18	0 (0)
	8	No	RCMV + KRV	45	34 (76)
Simultaneous viral inoculations¶	9	No	RCMV + CoxB4	8	1 (13)
	10	Yes	KRV	6	6 (100)
Sequential treatments**	11	Yes	RCMV	29	3 (10)
	12	Yes	Coxsackie B4	18	3 (17)
	13	Yes	Vaccinia	10	4 (40)
	14	Yes	H-1	6	0 (0)

Twenty- to 25-day-old male and female LEW0.1WR1 rats were inoculated intraperitoneally with the indicated viral agents with or without pretreatment with poly I:C as described in research design and methods. Doses were as follows: KRV, 10⁷ PFU; H-1, 10⁷ PFU; CoxB4, 10⁸ PFU; VV, 10⁶ PFU; or RCMV, 10⁴ PFU.

*Overall χ² for single virus inoculation category = 25.48, df = 5, P = 0.001.

†Group 3 vs. group 8, Fisher exact statistic, P = 0.0007.

‡Group 3 vs. group 11: Fisher exact statistic, P = 0.02.

§Group 4 vs. group 12, P = NS.

‖Group 5 vs. group 13, Fisher exact statistic, P = NS.

¶Group 8 vs. group 9, Fisher exact statistic, P = 0.001.

**Overall χ² for sequential treatments category = 25.58, df = 3, P < 0.001. In all experiments in which diabetes occurred, both male and female rats were affected. In groups 3 and 8 in which there were larger numbers of diabetic animals, both sexes were affected in approximately equal proportions.