Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Oct 6;59(1):228–235. doi: 10.2337/db09-0902

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

PMC Copyright notice

FIG. 1. — Increased angiogenesis and arteriogenesis in diabetic GK rats. A–D: Representative brain images of 10-week-old control (A and B, n = 9) and diabetic GK (C and D, n = 7) rats infused with Pu4ii indicate increased vascular tortuosity (corkscrew pattern) indicative of vascular remodeling and collateralization in diabetes. Arrow: collaterals between MCA and PCA or ACA; arrow head: anastomoses between MCA branches. E: Number of collaterals was significantly increased in 10-week-old GK rats compared with control but not in younger 5-week-old animals (n = 5 per group) before the onset of diabetes. In 10-week-old animals, the diameter of the collaterals (F), the anastomoses within the MCA tree (G), and the total microvessel density (H) were all increased in diabetes (n = 6 per group). *P < 0.05 vs. control. □, 5 weeks; ■, 10 weeks. (A high-quality color digital representation of this figure is available in the online issue.)