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. 2009 Oct 6;59(1):228–235. doi: 10.2337/db09-0902

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — Cerebrovascular permeability and matrix proteins are altered in diabetic GK rats. A: BBB permeability was significantly increased in diabetes (n = 6 per group). *P < 0.01. B: Occludin protein levels, evaluated by immunoblotting of brain microvessel and macrovessel homogenates and normalized to actin levels, were decreased in the microvasculature of diabetic rats (n = 8 per group). *P < 0.05 vs. control. There was no difference in microvessels or microvessel claudin-5 levels (C) or microvascular collagen IV levels (D) in control and diabetic animals (n = 8 per group). □, microvessel; ■, macrovessel.