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. 2009 Oct 6;59(1):228–235. doi: 10.2337/db09-0902

FIG. 3.

FIG. 3.

Effect of diabetes on extracellular matrix proteins and BDNF levels. MMP proteins are differentially regulated in the cerebrovasculature of diabetic rats. A: MMP-9 protein was increased in both vascular beds in diabetes (n = 6 per group). *P < 0.05 vs. control. □, microvessel; ■, macrovessel. B: MMP-2 protein was more abundant in the macrovessels and significantly increased in diabetes (n = 6 per group). *P < 0.05 vs. control; **P < 0.01 vs. microvessel. □, microvessel; ■, macrovessel. C: MMP-9 activity was increased in the macrovessels from diabetic rats. *P < 0.05 vs. control. □, MMP-2; ■, MMP-9. D: BDNF levels were higher in diabetes in both vascular beds (n = 5 per group). *P < 0.05 vs. control; **P < 0.05 vs. microvessel. □, microvessel; ■, macrovessel.