TABLE 6.
Frequency of the HLA haplotypes associated with protective effect in LADA and type 1 diabetes
| Protective HLA haplotypes | Type 1 diabetes (n = 119) |
LADA |
||||||
|---|---|---|---|---|---|---|---|---|
| Total (n = 121) |
Anti-GAD >0.11 (n = 56) |
Anti-GAD ≤0.11 (n = 65) |
||||||
| Frequency (n) | P* | Frequency (n) | P* | Frequency (n) | P* | Frequency (n) | P* | |
| DRB1*0402-DQA1*0301-DQB1*0302, TCTTG | 0.03 (3) | 0.0003 | 0.07 (9) | 0.092 | 0.04 (2) | 0.031 | 0.1 (7) | 0.731 |
| DRB1*0401-DQA1*0301-DQB1*0302, ATTG | 0.06 (7) | 2.94 × 10−10 | 0.18 (21) | 0.014 | 0.14 (8) | 0.012 | 0.21 (14) | 0.288 |
| DRB1*0901-DQA1*0301-DQB1*0303, TC | 0.06 (7) | 1.51 × 10−9 | 0.15 (18) | 0.003 | 0.11 (6) | 0.003 | 0.19 (12) | 0.203 |
| DRB1*1,501-DQA1*0102-DQB1*0602, CT | 0.03 (4) | 1.73 × 10−6 | 0.09 (11) | 0.025 | 0.06 (3) | 0.014 | 0.12 (8) | 0.418 |
| DRB1*0701-DQA1*0201-DQB1*0303, TGC | 0.2 (24) | 7.67 × 10−6 | 0.29 (35) | 0.123 | 0.24 (13) | 0.027 | 0.34 (22) | 0.922 |
| DRB1*0401-DQA1*0301-DQB1*0301, ATG | 0.04 (4) | 8.28 × 10−9 | 0.12 (14) | 0.005 | 0.1 (6) | 0.017 | 0.13 (9) | 0.093 |
| DRB1*0403-DQA1*0301-DQB1*0302, TTGTA | 0.02 (2) | 1.46 × 10−5 | 0.09 (11) | 0.349 | 0.07 (4) | 0.167 | 0.11 (7) | 0.993 |
*P value corrected for age, sex, and BMI.