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. 2009 Sep 30;59(1):51–60. doi: 10.2337/db09-0336

FIG. 2.

FIG. 2.

Effect of combination gene therapy on myocardial fibrosis 7 and 30 days after gene therapy. A: Representative images show myocardial infarct and fibrosis after 7 days of MI and combination gene therapy. B: Representative images show myocardial infarct and fibrosis after 30 days of MI and combination gene therapy. There is no evident fibrosis in the CS and DS groups. A thinner infarct and significant fibrosis is evident in the CLZMI and DLZMI groups. Combination gene therapy in the CVAMI and DVAMI groups resulted in a thicker infarct containing islands of viable cardiac tissue. CS, nondiabetic control sham; DS, diabetic sham; CLZMI, nondiabetic control animals that received Ad.LacZ injections; DLZMI, diabetic animals that received Ad.LacZ injections; CVAMI, nondiabetic control animals that received combination gene therapy; and DVAMI, diabetic animals that received combination gene therapy. (A high-quality color digital representation of this figure is available in the online issue.)