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. 2009 Sep 30;59(1):51–60. doi: 10.2337/db09-0336

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — Effect of combination gene therapy on capillary and arteriolar density 7 days after the intervention. Representative images (A) and graphical representation (B) of capillary density analysis among the different groups (counts/mm²). Representative images (C) and graphical representation (D) of arteriolar density analysis among the different groups (counts/mm²). There was a significant increase in the capillary and arteriolar density in the CVAMI and DVAMI groups compared with the CLZMI and DLZMI groups, respectively. CS (black solid bar), nondiabetic control sham; DS (gray solid bar), diabetic sham; CLZMI (white bar), nondiabetic control animals that received Ad.LacZ injections; DLZMI (diagonal brick bar), diabetic animals that received Ad.LacZ injections; CVAMI (wave bar), nondiabetic control animals that received combination gene therapy; and DVAMI (wide upward diagonal bar), diabetic animals that received combination gene therapy. Values are presented as mean ± SEM. *P ≤ 0.05 when DS is compared with CS, #P ≤ 0.05 compared with CLZMI, †P ≤ 0.05 when DVAMI is compared with DLZMI. (A high-quality color digital representation of this figure is available in the online issue.)